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That changed after chemist Bruce Merrifield developed solid-phase peptide synthesis, a breakthrough that earned him the Nobel Prize in 1984 and dramatically simplified production of these fragile biomolecules by allowing them to be built much more efficiently compared to purification
doi:10.1093/sleep/15.6.519 Mu X, Qu L, Yin L, Wang L, Liu X, Liu D
Published trials remain limited in size and scope
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